用甘氨胆酸钠处理对大鼠肥大细胞中钙激活的三磷酸腺苷酶去除的影响。
Effect of removal of calcium-activated adenosine triphosphatase from rat mast cells by treatment with sodium glycocholate.
作者信息
Cooper P H, Stanworth D R
出版信息
Biochem J. 1977 Dec 15;168(3):583-5. doi: 10.1042/bj1680583.
Abstract
Sodium glycocholate was shown to remove a Ca2+-activated adenosine triphosphatase from the external surface of the rat mast cell without causing lysis. Sensitized mast cells pretreated with sodium glycocholate showed a decrease in histamine-releasing capacity when triggered with antigen, Synacthen and ATP. Release induced by calcium ionophore A23187 was unaffected.
摘要
已表明甘氨胆酸钠可从大鼠肥大细胞外表面去除一种钙激活的三磷酸腺苷酶，而不引起细胞裂解。用甘氨胆酸钠预处理的致敏肥大细胞在受到抗原、合成促肾上腺皮质激素和三磷酸腺苷刺激时，组胺释放能力降低。钙离子载体A23187诱导的释放不受影响。
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