Nicklas B J, Goldberg A P, Bunyard L B, Poehlman E T
Department of Medicine, University of Maryland School of Medicine, Baltimore, USA.
Am J Clin Nutr. 1995 Nov;62(5):918-22. doi: 10.1093/ajcn/62.5.918.
Lipolysis is increased in upper-body obese individuals but it is unclear whether body fat distribution is associated with differences in resting metabolic rate (RMR) and/or substrate oxidation in older women. This study determined whether RMR and lipid oxidation are higher in postmenopausal women with visceral obesity. A single-slice computed tomography scan was taken midway between L4 and L5 in 29 women aged 52-72 y with a fat mass of 29.2-68.8 kg. RMR and lipid oxidation rates were measured by using indirect calorimetry. RMR was related to waist circumference (r = 0.45, P < 0.05), but not to waist-hip ratio (WHR; r = 0.23) or intraabdominal fat area (r = 0.26). However, there was a strong, positive relation between lipid oxidation and intraabdominal fat area (r = 0.57, P < 0.01), waist circumference (r = 0.54, P < 0.01), and WHR (r = 0.42, P < 0.05). These correlations remained significant after statistical adjustment for total fat and fat-free mass. These results suggest that in postmenopausal women higher amounts of intraabdominal fat are associated with an enhanced rate of lipid oxidation independent of total adiposity, but not with alterations in RMR.
上半身肥胖个体的脂肪分解增加，但尚不清楚身体脂肪分布是否与老年女性静息代谢率（RMR）和/或底物氧化的差异有关。本研究确定了内脏肥胖的绝经后女性的RMR和脂质氧化是否更高。对29名年龄在52 - 72岁、脂肪量为29.2 - 68.8 kg的女性，在L4和L5中间位置进行单层计算机断层扫描。通过间接量热法测量RMR和脂质氧化率。RMR与腰围相关（r = 0.45，P < 0.05），但与腰臀比（WHR；r = 0.23）或腹内脂肪面积（r = 0.26）无关。然而，脂质氧化与腹内脂肪面积（r = 0.57，P < 0.01）、腰围（r = 0.54，P < 0.01）和WHR（r = 0.42，P < 0.05）之间存在强正相关。在对总脂肪和去脂体重进行统计调整后，这些相关性仍然显著。这些结果表明，在绝经后女性中，较高的腹内脂肪量与脂质氧化率增加相关，且独立于总体肥胖程度，但与RMR的改变无关。
