Asbury R, Blessing J A, Smith D M, Carson L F
Department of Oncology, University of Rochester School of Medicine, NY, USA.
Am J Clin Oncol. 1995 Oct;18(5):397-9. doi: 10.1097/00000421-199510000-00007.
Aminothiadiazole was used to treat 21 patients with metastatic or recurrent leiomyosarcoma of the uterus. All patients received a starting dose of aminothiadiazole of 125 mg/m2 intravenously (30-to-45-minute infusion), which was repeated at weekly intervals. All patients also took allopurinol 300 mg per day orally to prevent hyperuricemia, a side effect of aminothiadiazole. Five patients (25%) had stable disease but there were no objective responses. Toxicity was generally mild with this regimen. There was no life-threatening toxicity and only three episodes of severe toxicity. One patient experienced both grade 3 leukopenia and thrombocytopenia, while another patient had grade 3 nausea and vomiting. Further studies in this disease are not planned.
氨噻二唑被用于治疗21例子宫转移性或复发性平滑肌肉瘤患者。所有患者静脉注射氨噻二唑的起始剂量为125 mg/m²（输注30至45分钟），每周重复一次。所有患者还口服300 mg别嘌醇以预防氨噻二唑的副作用高尿酸血症。5例患者（25%）病情稳定，但无客观缓解。该治疗方案的毒性一般较轻。没有危及生命的毒性，只有3次严重毒性发作。1例患者出现3级白细胞减少和血小板减少，另1例患者出现3级恶心和呕吐。未计划对该疾病进行进一步研究。
