Asbury R, Blessing J A, Moore D
Department of Medicine in Oncology, University of Rochester School of Medicine, NY, USA.
Am J Clin Oncol. 1996 Aug;19(4):400-2. doi: 10.1097/00000421-199608000-00017.
Aminothiadiazole (NSC 4728) is an analog of the thiadiazoles, a group of drugs that stimulated interest because they do not cause significant myelosuppression and have a unique ability to increase uric acid production unrelated to tissue damage. Previous articles have reported results in ovarian cancer, squamous cell cervical cancer, nonsquamous cell cervical cancer, and endometrial cancer. The Gynecologic Oncology Group chose to study aminothiadiazole in patients with mixed mesodermal tumors of the uterus refractory to prior chemotherapy. Twenty-two patients were entered into this study. Eligibility required that patients had histologically confirmed measurable malignancy. All patients received a starting dose of aminothiadiazole of 125 mg/m2 intravenously (30-45 min infusion) repeated at weekly intervals. All patients also took allopurinol, 300 mg orally per day, to prevent hyperuricemia. Subsequent therapy was not given unless the white blood cell count was > 3,000/microliters and platelets were > 100,000/microliters prior to treatment. One patient (5%) in this study had a partial response, which lasted only 1.2 months. The site of this response was a mesenteric mass. Most patients in this study had no toxicity whatsoever, and no life-threatening toxicity was seen. There were no complete responses. Aminothiadiazole in this dose schedule appears to have no utility in previously treated patients with mixed mesodermal tumors of the uterus.
氨基噻二唑（NSC 4728）是噻二唑类的一种类似物，这类药物引发了人们的兴趣，因为它们不会导致明显的骨髓抑制，并且具有一种与组织损伤无关的独特能力，即增加尿酸生成。此前的文章报道了其在卵巢癌、宫颈鳞状细胞癌、宫颈非鳞状细胞癌和子宫内膜癌中的研究结果。妇科肿瘤学组选择对先前化疗难治的子宫混合性中胚叶肿瘤患者研究氨基噻二唑。22例患者进入该研究。入选标准要求患者有组织学确诊的可测量恶性肿瘤。所有患者静脉注射氨基噻二唑的起始剂量为125 mg/m²（输注30 - 45分钟），每周重复一次。所有患者还口服别嘌醇，每日300 mg，以预防高尿酸血症。除非治疗前白细胞计数>3000/微升且血小板>100000/微升，否则不给予后续治疗。本研究中有1例患者（5%）出现部分缓解，仅持续1.2个月。缓解部位为肠系膜肿块。本研究中的大多数患者没有任何毒性反应，也未见危及生命的毒性反应。没有完全缓解的病例。按照该剂量方案使用氨基噻二唑，对于先前治疗过的子宫混合性中胚叶肿瘤患者似乎没有疗效。
