针刺对大鼠实验性高胆红素血症和胆管炎的保护作用。

Acupuncture protection against experimental hyperbilirubinemia and cholangitis in rats.

作者信息

Lin J G, Yang S H, Tsai C H

机构信息

Graduate Institute of Chinese Medical Science, China Medical College, Taichung, Taiwan.

出版信息

Am J Chin Med. 1995;23(2):131-7. doi: 10.1142/S0192415X95000171.

DOI:10.1142/S0192415X95000171

PMID:7572773

Abstract

Effects of acupuncture on experimental hyperbilirubinemia and cholangitis were studied in male rats (n = 33). The experimental group were treated with acupuncture, 18, 12 and 6 hr prior to and 6, 12 and 18 hr after oral administration of alpha-napthylisothiocyanate (ANIT, 100 mg per Kg). Rats were sacrificed 48 hours after challenge. Serum and liver samples were taken for biochemical and histological analysis, respectively. Results of this study revealed that rats treated with ANIT exhibited elevations in bilirubin, SGOT and SGPT as well as cholangitis. In rats receiving acupuncture and ANIT, biochemical and morphological parameters of liver injury were significantly reduced. Acupuncture therapy may be able to prevent ANIT-induced hyperbilirubinemia and cholangitis.

摘要

在雄性大鼠（n = 33）中研究了针刺对实验性高胆红素血症和胆管炎的影响。实验组在口服α-萘基异硫氰酸酯（ANIT，每千克100毫克）之前18、12和6小时以及之后6、12和18小时接受针刺治疗。激发后48小时处死大鼠。分别采集血清和肝脏样本进行生化和组织学分析。本研究结果显示，接受ANIT治疗的大鼠胆红素、谷草转氨酶和谷丙转氨酶升高，同时伴有胆管炎。在接受针刺和ANIT治疗的大鼠中，肝损伤的生化和形态学参数显著降低。针刺疗法可能能够预防ANIT诱导的高胆红素血症和胆管炎。