Howden C W, Hornung C A
Department of Internal Medicine, University of South Carolina School of Medicine, Columbia, USA.
Am J Gastroenterol. 1995 Oct;90(10):1814-9.
Patients with Barrett's esophagus may be at increased risk of colon neoplasms, including cancer. However, different studies of this have yielded conflicting results. The objective of this analysis was to review all existing published data in an attempt to determine whether there is such an association and, if so, to estimate the level of risk.
We have reviewed all of the published studies examining the prevalence of colon neoplasms in patients with Barrett's esophagus. We have compared these with a cohort of patients drawn from the general population and participating in colorectal cancer screening programs.
The prevalence of colon cancer in patients with Barrett's esophagus was 7.6% compared with 1.6% in the control group. The pooled odds ratio for colon cancer in Barrett's esophagus was 5.19 (p < 0.0001). In a small subgroup analysis, the odds ratio for colon cancer in patients identified as having Barrett's esophagus with specialized columnar epithelium was 8.71 (p < 0.0001).
We conclude that patients with Barrett's esophagus have an increased risk of colon cancer. This may be particularly true in those patients with specialized columnar epithelium.
巴雷特食管患者患包括癌症在内的结肠肿瘤的风险可能会增加。然而，对此的不同研究得出了相互矛盾的结果。本分析的目的是回顾所有已发表的现有数据，以试图确定是否存在这种关联，如果存在，则估计风险水平。
我们回顾了所有已发表的研究，这些研究调查了巴雷特食管患者结肠肿瘤的患病率。我们将这些患者与从普通人群中抽取并参加结直肠癌筛查项目的一组患者进行了比较。
巴雷特食管患者的结肠癌患病率为7.6%，而对照组为1.6%。巴雷特食管患者患结肠癌的合并比值比为5.19（p<0.0001）。在一项小型亚组分析中，被确定为具有特殊柱状上皮的巴雷特食管患者患结肠癌的比值比为8.71（p<0.0001）。
我们得出结论，巴雷特食管患者患结肠癌的风险增加。在那些具有特殊柱状上皮的患者中可能尤其如此。
