Duerksen D R, Blondel-Hill E, Bailey R J
Department of Medicine, University of Alberta, Edmonton, Canada.
Am J Gastroenterol. 1995 Oct;90(10):1886-7.
The etiology of primary sclerosing cholangitis, a chronic progressive cholestatic liver disease, is poorly understood. Treatment with oral methotrexate may improve patient symptoms, liver biochemistry, and hepatic histology. This report describes a severe life-threatening complication of methotrexate therapy in primary sclerosing cholangitis--the development of Pneumocystis carinii pneumonia. The reported cases of methotrexate-associated P. carinii pneumonia in the literature are reviewed. With the increasing use of methotrexate in chronic inflammatory disorders, physicians should be aware of this potentially lethal complication.
原发性硬化性胆管炎是一种慢性进行性胆汁淤积性肝病，其病因尚不清楚。口服甲氨蝶呤治疗可能改善患者症状、肝脏生化指标及肝脏组织学。本报告描述了原发性硬化性胆管炎中甲氨蝶呤治疗的一种严重的危及生命的并发症——卡氏肺孢子虫肺炎的发生。本文回顾了文献中报道的与甲氨蝶呤相关的卡氏肺孢子虫肺炎病例。随着甲氨蝶呤在慢性炎症性疾病中的使用增加，医生应意识到这种潜在的致命并发症。
