Flood D A, Chan C K, Pruzanski W
Department of Medicine, Wellesley and Princess Margaret Hospitals, University of Toronto, ON, Canada.
J Rheumatol. 1991 Aug;18(8):1254-6.
Opportunistic infections occur in patients with rheumatic diseases treated with low dose methotrexate (MTX) with or without other immunosuppressants. Our case report illustrates a fatal case of Pneumocystis carinii pneumonia in a patient with rheumatoid arthritis treated with low dose MTX and glucocorticoid. A review of the literature reveals other opportunistic infections such as Cryptococcus, Nocardia, and herpes zoster presenting in such patients. These occurrences suggest that MTX should be used cautiously in patients with rheumatic disease receiving concomitant medical therapy.
机会性感染发生在用低剂量甲氨蝶呤（MTX）治疗的风湿性疾病患者中，无论是否联用其他免疫抑制剂。我们的病例报告展示了1例在用低剂量MTX和糖皮质激素治疗的类风湿关节炎患者中发生的卡氏肺孢子虫肺炎致死病例。文献综述显示，此类患者还会出现其他机会性感染，如隐球菌、诺卡菌和带状疱疹。这些情况表明，在接受其他药物治疗的风湿性疾病患者中应谨慎使用MTX。
