Herrera C R, D'Agostino R B, Gerstman B B, Bosco L A, Belanger A J
Department of Internal Medicine, School of Medicine, University of Texas at Houston, USA.
Am J Epidemiol. 1995 Oct 15;142(8):828-33. doi: 10.1093/oxfordjournals.aje.a117722.
The authors assessed the relation between the extent and progression of baldness and coronary heart disease. Baldness was assessed twice, in 1956 and in 1962, in a cohort of 2,017 men from Framingham, Massachusetts. Extent of baldness was classified in terms of number of bald areas: no areas bald (n = 153), one area bald (n = 420), two areas bald (n = 587), and all areas bald (n = 857). Men who were assessed both times and who had two or fewer bald areas during the first evaluation were classified into one of three groups: "mild or no progression," "moderate progression," or "rapid progression." The cohort was followed for up to 30 years for new occurrences of coronary heart disease, coronary heart disease death, cardiovascular disease, and death due to any cause. The relations between the extent and progression of baldness and the aforementioned outcomes were assessed using a Cox proportional hazards model, adjusting for age and other known cardiovascular disease risk factors. Extent of baldness was not associated with any of the outcomes. However, the amount of progression of baldness was associated with coronary heart disease occurrence (relative risk (RR) = 2.4, 95% confidence interval (CI) 1.3-4.4), coronary heart disease mortality (RR = 3.8, 95% CI 1.9-7.7), and all-cause mortality (RR = 2.4, 95% CI 1.5-3.8). Rapid hair loss may be a marker for coronary heart disease.
作者评估了秃发程度及进展与冠心病之间的关系。1956年和1962年，对来自马萨诸塞州弗雷明汉的2017名男性队列进行了两次秃发评估。秃发程度根据秃发区域数量分类：无秃发区域（n = 153）、一个秃发区域（n = 420）、两个秃发区域（n = 587）以及全秃（n = 857）。两次均接受评估且在首次评估时秃发区域为两个及以下的男性被分为三组之一：“轻度或无进展”、“中度进展”或“快速进展”。对该队列随访长达30年，观察冠心病新发病例、冠心病死亡、心血管疾病以及任何原因导致的死亡情况。使用Cox比例风险模型评估秃发程度及进展与上述结局之间的关系，并对年龄和其他已知的心血管疾病风险因素进行了校正。秃发程度与任何结局均无关联。然而，秃发进展程度与冠心病发病（相对风险（RR）= 2.4，95%置信区间（CI）1.3 - 4.4）、冠心病死亡率（RR = 3.8，95% CI 1.9 - 7.7）以及全因死亡率（RR = 2.4，95% CI 1.5 - 3.8）相关。快速脱发可能是冠心病的一个标志物。
