Triantafyllidi Helen, Grafakos Agis, Ikonomidis Ignatios, Pavlidis George, Trivilou Paraskevi, Schoinas Antonis, Lekakis John
2nd Department of Cardiology Medical School, Attikon Hospital, University of Athens, Athens, Greece.
J Clin Hypertens (Greenwich). 2017 Jan;19(1):51-57. doi: 10.1111/jch.12871. Epub 2016 Jul 1.
An association between androgenic alopecia (AGA), coronary artery disease, and hypertension has been reported in previous epidemiological studies. The authors evaluated the relationship of target organ damage caused by hypertension with AGA in 101 newly diagnosed and untreated hypertension men with mild to moderate AGA (AGA ), severe AGA (AGA ), and non-AGA. Pulse wave velocity (PWV), office and 24-hour pulse pressure (PP), carotid intima-media thickness (IMT), left ventricular hypertrophy (LVH), coronary flow reserve (CFRd), and AGA severity by Hamilton-Norwood scale were estimated. CFRd was significantly impaired in AGA patients compared with AGA (P=.007) and non-AGA patients (P=.02). No differences were found within groups regarding PWV, PP, IMT, and LVH. AGA severity was related to CFRd (independently) and PP while AGA duration and age of onset were related to CFRd and PP, respectively. The authors conclude that impaired coronary microcirculation and aortic stiffness might precede the appearance of significant stenotic coronary lesions in hypertensive patients with severe AGA. In addition, hypertensive patients with severe and early AGA onset seem to be exposed to an augmented cardiovascular risk.
既往流行病学研究报道了雄激素性脱发（AGA）、冠状动脉疾病和高血压之间的关联。作者评估了101例新诊断且未治疗的高血压男性患者中，高血压所致靶器官损害与AGA的关系，这些患者分为轻度至中度AGA（AGA）组、重度AGA（AGA）组和非AGA组。评估了脉搏波速度（PWV）、诊室及24小时脉压（PP）、颈动脉内膜中层厚度（IMT）、左心室肥厚（LVH）、冠状动脉血流储备（CFRd）以及根据汉密尔顿-诺伍德量表评估的AGA严重程度。与AGA组（P = 0.007）和非AGA组（P = 0.02）相比，AGA患者的CFRd明显受损。在PWV、PP、IMT和LVH方面，各组之间未发现差异。AGA严重程度与CFRd（独立相关）和PP相关，而AGA病程和发病年龄分别与CFRd和PP相关。作者得出结论，在患有重度AGA的高血压患者中，冠状动脉微循环受损和主动脉僵硬度增加可能先于明显的冠状动脉狭窄病变出现。此外，重度且早发型AGA的高血压患者似乎面临更高的心血管风险。
