Glazer L C, Maguire A, Blumenkranz M S, Trese M T, Green W R
Rush Medical College, Chicago, Illinois, USA.
Am J Ophthalmol. 1995 Oct;120(4):471-9. doi: 10.1016/s0002-9394(14)72661-3.
To evaluate current surgical results in patients with familial exudative vitreoretinopathy and study the histologic findings of epiretinal membranes obtained at the time of surgery.
We performed phakic pars plana vitrectomy and membrane peeling on five patients (six eyes) with familial exudative vitreoretinopathy, who ranged in age from 18 months to 9 years and had traction retinal detachment. Membranes from two eyes (two patients) were analyzed by light and electron microscopy.
The macula was reattached in all six eyes. Visual acuity improved after surgery in five of the six eyes, with two eyes improving from a preoperative visual acuity of 20/400 to a postoperative visual acuity of 20/25 and 20/60. Electron microscopic analysis of the membranes from two patients disclosed thick fibrocellular fragments with vascular elements and astrocytes.
With current surgical techniques, there appears to be improvement in the anatomic reattachment rate and visual outcome in patients with familial exudative vitreoretinopathy. Amblyopia, reproliferation, and vitreous hemorrhage may limit long-term improvement in vision.
评估家族性渗出性玻璃体视网膜病变患者当前的手术效果，并研究手术时获得的视网膜前膜的组织学表现。
我们对5例（6只眼）年龄在18个月至9岁之间、患有牵引性视网膜脱离的家族性渗出性玻璃体视网膜病变患者进行了有晶状体眼的扁平部玻璃体切除术和膜剥除术。对2只眼（2例患者）的膜进行了光镜和电镜分析。
所有6只眼的黄斑均重新附着。6只眼中有5只眼术后视力提高，其中2只眼术前视力为20/400，术后视力提高到20/25和20/60。对2例患者的膜进行电镜分析发现，有含血管成分和星形胶质细胞的厚纤维细胞碎片。
采用当前的手术技术，家族性渗出性玻璃体视网膜病变患者的解剖复位率和视觉效果似乎有所改善。弱视、再增殖和玻璃体出血可能会限制视力的长期改善。
