Markowitz J C, Klerman G L, Clougherty K F, Spielman L A, Jacobsberg L B, Fishman B, Frances A J, Kocsis J H, Perry S W
Department of Psychiatry, Cornell University Medical College, New York, NY 10021, USA.
Am J Psychiatry. 1995 Oct;152(10):1504-9. doi: 10.1176/ajp.152.10.1504.
The authors present preliminary data from two treatment modalities of a randomized clinical trial in which they compared 16-week interventions of interpersonal psychotherapy to supportive psychotherapy.
HIV-positive patients who were not acutely medically ill and had scores of 15 or higher on the Hamilton Depression Rating Scale were randomly assigned to one of four treatment modalities. They were assessed by the Hamilton scale and Beck Depression Inventory at 8 and 16 weeks. Most subjects who underwent either interpersonal psychotherapy (N = 16) or supportive psychotherapy (N = 16) were male, gay or bisexual, white, and college educated.
Results of last-observation-carried-forward and completer analyses showed that scores on the Hamilton scale and Beck Depression Inventory decreased significantly for both treatments. Differential improvement for interpersonal psychotherapy appeared by midtreatment (week 8) and persisted at termination.
This is the first controlled study of individual psychotherapies for depressed HIV-positive patients. Results suggest that a specific antidepressant psychotherapy, interpersonal psychotherapy, has advantages over a supportive therapy.
作者展示了一项随机临床试验两种治疗方式的初步数据，该试验比较了为期16周的人际心理治疗与支持性心理治疗。
未患有急性疾病且汉密尔顿抑郁量表得分在15分或以上的HIV阳性患者被随机分配到四种治疗方式之一。在第8周和第16周时，通过汉密尔顿量表和贝克抑郁量表对他们进行评估。接受人际心理治疗（N = 16）或支持性心理治疗（N = 16）的大多数受试者为男性、同性恋或双性恋、白人且受过大学教育。
末次观察结转分析和完成者分析结果显示，两种治疗方式下汉密尔顿量表和贝克抑郁量表的得分均显著下降。人际心理治疗的差异改善在治疗中期（第8周）出现，并在治疗结束时持续存在。
这是第一项针对抑郁的HIV阳性患者的个体心理治疗对照研究。结果表明，一种特定的抗抑郁心理治疗——人际心理治疗，比支持性治疗更具优势。
