重组白细胞介素-12对小鼠鸟分枝杆菌感染的保护作用。
Protection of mice from Mycobacterium avium infection by recombinant interleukin-12.
作者信息
Kobayashi K, Kasama T, Yamazaki J, Hosaka M, Katsura T, Mochizuki T, Soejima K, Nakamura R M
机构信息
First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
出版信息
Antimicrob Agents Chemother. 1995 Jun;39(6):1369-71. doi: 10.1128/AAC.39.6.1369.
Abstract
Treatment with interleukin-12 (IL-12) significantly reduced the number of viable bacteria in mice infected with Mycobacterium avium. IL-12 itself, however, could not inhibit directly mycobacterial growth in vitro. IL-12 exerts antimycobacterial activity in vivo with a low level of toxicity, possibly by enhancing the host defense against the infection.
摘要
用白细胞介素-12（IL-12）治疗可显著减少感染鸟分枝杆菌的小鼠体内活菌数量。然而，IL-12本身在体外并不能直接抑制分枝杆菌生长。IL-12可能通过增强宿主对感染的防御作用，在体内发挥抗分枝杆菌活性且毒性较低。
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