重组白细胞介素-12对小鼠鸟分枝杆菌感染的保护作用。
Protection of mice from Mycobacterium avium infection by recombinant interleukin-12.
作者信息
Kobayashi K, Kasama T, Yamazaki J, Hosaka M, Katsura T, Mochizuki T, Soejima K, Nakamura R M
机构信息
First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
出版信息
Antimicrob Agents Chemother. 1995 Jun;39(6):1369-71. doi: 10.1128/AAC.39.6.1369.
Abstract
Treatment with interleukin-12 (IL-12) significantly reduced the number of viable bacteria in mice infected with Mycobacterium avium. IL-12 itself, however, could not inhibit directly mycobacterial growth in vitro. IL-12 exerts antimycobacterial activity in vivo with a low level of toxicity, possibly by enhancing the host defense against the infection.
摘要
用白细胞介素-12（IL-12）治疗可显著减少感染鸟分枝杆菌的小鼠体内活菌数量。然而，IL-12本身在体外并不能直接抑制分枝杆菌生长。IL-12可能通过增强宿主对感染的防御作用，在体内发挥抗分枝杆菌活性且毒性较低。
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本文引用的文献
1
Immunity to intracellular bacteria.对细胞内细菌的免疫
Annu Rev Immunol. 1993;11:129-63. doi: 10.1146/annurev.iy.11.040193.001021.
2
Resistance to nitric oxide in Mycobacterium avium complex and its implication in pathogenesis.鸟分枝杆菌复合群对一氧化氮的抗性及其在发病机制中的意义。
Infect Immun. 1993 May;61(5):1980-9. doi: 10.1128/iai.61.5.1980-1989.1993.
3
Recombinant granulocyte-macrophage colony-stimulating factor enhances the effects of antibiotics against Mycobacterium avium complex infection in the beige mouse model.
J Infect Dis. 1994 Mar;169(3):575-80. doi: 10.1093/infdis/169.3.575.
4
Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.白细胞介素12是细胞内寄生虫不依赖T淋巴细胞诱导γ干扰素所必需的，并能在T细胞缺陷宿主中诱导抗性。
Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6115-9. doi: 10.1073/pnas.90.13.6115.
5
Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response.皮肤利什曼病的消退：白细胞介素12引发保护性1型辅助性T细胞免疫反应。
J Exp Med. 1993 Jun 1;177(6):1797-802. doi: 10.1084/jem.177.6.1797.
6
Recombinant interleukin 12 cures mice infected with Leishmania major.重组白细胞介素12可治愈感染硕大利什曼原虫的小鼠。
J Exp Med. 1993 May 1;177(5):1505-9. doi: 10.1084/jem.177.5.1505.
7
IL-12: initiation cytokine for cell-mediated immunity.白细胞介素-12：细胞介导免疫的起始细胞因子。
Science. 1993 Apr 23;260(5107):496-7. doi: 10.1126/science.8097337.
8
The role of interleukin 12 in the immune response, disease and therapy.白细胞介素12在免疫反应、疾病及治疗中的作用。
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9
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J Clin Invest. 1994 Apr;93(4):1733-9. doi: 10.1172/JCI117157.
10
Progress in TB research: Robert Koch's dilemma revisited.
Immunol Today. 1994 Jan;15(1):1-4. doi: 10.1016/0167-5699(94)90015-9.
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