Wulf H C
Arch Dermatol Res. 1978;263(1):37-46.
The acute effect of 8-methoxypsoralen (8-MOP) and 8-MOP + long wave ultraviolet light (UVA) on sister chromatid exchange (SCE) has been examined in an in vitro experiment. The SCE count was significantly increased by 8-MOP without light, but the effect was substantially greater (50%) by 8-MOP + UVA. In addition, mitoses with banded staining of the chromosomes were seen after 8-MOP and UVA. These changes were dose dependent, and they might be responsible for the reduced cell turnover in psoriasis plaque after PUVA.
在一项体外实验中，研究了8-甲氧基补骨脂素（8-MOP）以及8-甲氧基补骨脂素加长波紫外线（UVA）对姐妹染色单体交换（SCE）的急性影响。未照射光时，8-MOP可使SCE计数显著增加，但8-MOP加UVA时的影响则显著更大（增加50%）。此外，8-MOP和UVA照射后可见染色体带型染色的有丝分裂。这些变化呈剂量依赖性，它们可能是导致光化学疗法（PUVA）后银屑病斑块中细胞更新减少的原因。
