一名患有广泛硬化萎缩性苔藓患者皮肤和尿液中的酸性糖胺聚糖。
Acidic glycosaminoglycans in skin and urine of a patient with wide-spreaded lichen sclerosus et atrophicus.
作者信息
Yoshima H, Shinkai H, Sano S, Homma M
出版信息
Arch Dermatol Res. 1978;263(1):59-66.
PMID:757458
Abstract
Changes of dermal and urinary acidic glycosaminoglycans in Lichen Sclerosus et Atrophicus (LSA) were investigated with the following results: 1. Hyaluronic acid (HA) was excreted in urine of a patient with LSA. 2. HA and low sulfate chondroitin were eluted with 0.5 M NaCl by Bio Rad AG 1- x 2 (Cl- form) column chromatography. 3. Involved dermal tissue contained only about 50% of HA in the skin of a healthy adult.
摘要
对硬化萎缩性苔藓（LSA）患者皮肤和尿液中的酸性糖胺聚糖变化进行了研究，结果如下：1. 一名LSA患者的尿液中排出了透明质酸（HA）。2. 通过Bio Rad AG 1-x 2（Cl-型）柱色谱法，用0.5M NaCl洗脱HA和低硫酸软骨素。3. 受累皮肤组织中HA的含量仅约为健康成年人皮肤中HA含量的50%。
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