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[病例报告:使用可植入储液器系统经动脉灌注免疫化疗使IV期子宫颈癌完全缓解]

[A case report: complete remission of stage IV uterine cervix carcinoma by immuno-chemotherapy with intraarterial infusion using implantable reservoir system].

作者信息

Shimizu A, Watanabe S, Okuyama D, Morioka M, Yoda A, Hoshino K, Noguchi Y, Takahashi J, Notake Y, Mitsuya T

机构信息

Dept. of Obstetrics and Gynecology, Showa University Fujigaoka Hospital.

出版信息

Gan To Kagaku Ryoho. 1995 Sep;22(11):1706-10.

PMID:7574798
Abstract

A patient with neck lymph node metastasis from squamous carcinoma of the uterine cervix was treated by immunotherapy and neo-adjuvant intraarterial infusion chemotherapy (OK-432 ic, etoposide 25 mg/body x 7 days po, CDDP 100 mg/m2/5 hr iA, CPM 200 mg/body iv, THP 50 mg/m2/2 hr iA). Three courses of the neo-adjuvant chemotherapy were given. After the first course, the neck metastatic tumor appeared remarkably small. After the second, the neck tumor disappeared and the uterine tumor appeared small and to have good movement. Hysterectomy was performed one month after. Each tissue platina concentration (microgram/cm3) is 9.12 uterus cervix, 10.9 uterus corporis, 8.17 fallopian tube, 14.0 ovarium, 1.47-0.88 pelvic lymph node. This patient was treated with irradiation after operation, and is presently in a state of cytological complete remission. Now she continues maintenance immunochemotherapy with UFT and OK-432 with a home doctor.

摘要

一名子宫颈鳞状细胞癌颈部淋巴结转移患者接受了免疫治疗和新辅助动脉内灌注化疗(OK-432 瘤内注射,依托泊苷 25mg/体×7 天口服,顺铂 100mg/m²/5 小时动脉内注射,环磷酰胺 200mg/体静脉注射,吡柔比星 50mg/m²/2 小时动脉内注射)。给予三个疗程的新辅助化疗。第一个疗程后,颈部转移瘤明显变小。第二个疗程后,颈部肿瘤消失,子宫肿瘤变小且活动度良好。一个月后进行了子宫切除术。各组织铂浓度(微克/立方厘米)分别为:子宫颈 9.12、子宫体 10.9、输卵管 8.17、卵巢 14.0、盆腔淋巴结 1.47 - 0.88。该患者术后接受了放疗,目前处于细胞学完全缓解状态。现在她在家医的指导下继续使用优福定和 OK-432 进行维持免疫化疗。

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