Sarafino E P, Goldfedder J
Department of Psychology, Trenton State College, NJ 08650, USA.
Arch Dis Child. 1995 Aug;73(2):112-6. doi: 10.1136/adc.73.2.112.
The role of heredity in the presence of asthma, severity of the condition, and impact of 12 specific triggers of attacks was investigated. Health surveys containing questions about children's asthma characteristics were completed by 325 families with twin children across the United States. Data for 39 monozygotic twin pairs and 55 same sex dizygotic twin pairs who were between 2 and 20 years of age and had asthma present in at least one member of each pair were received and analysed. Results revealed higher concordance for the presence of asthma among monozygotic (58.97%; n = 23) than dizygotic twins (23.64%; n = 13). Further analyses were restricted to data from the concordant monozygotic and dizygotic twin pairs. Asthma severity (the product of attack frequency and intensity ratings) was significantly correlated for monozygotic pairs but not for dizygotic pairs, and this difference in monozygotic and dizygotic severity correlations was significant. Also, monozygotic twins showed significantly higher correlations than dizygotic twins for the impacts of two asthma triggers: respiratory infection and physical activity. These results indicate a role of heredity in the presence of asthma and suggest that genetic factors may also affect the severity of children's asthma condition and the impact of respiratory infection and physical exertion as asthma triggers.
研究了遗传因素在哮喘发生、病情严重程度以及12种特定发作诱因影响方面的作用。全美325个有双胞胎子女的家庭完成了包含有关儿童哮喘特征问题的健康调查。接收并分析了39对同卵双胞胎和55对同性异卵双胞胎的数据，这些双胞胎年龄在2至20岁之间，且每对双胞胎中至少有一人患有哮喘。结果显示，同卵双胞胎中哮喘发生率的一致性（58.97%；n = 23）高于异卵双胞胎（23.64%；n = 13）。进一步的分析仅限于来自一致的同卵和异卵双胞胎对的数据。哮喘严重程度（发作频率和强度评分的乘积）在同卵双胞胎对中显著相关，而异卵双胞胎对中则不然，并且同卵和异卵双胞胎严重程度相关性的这种差异具有显著性。此外，在两种哮喘诱因（呼吸道感染和体育活动）的影响方面，同卵双胞胎的相关性显著高于异卵双胞胎。这些结果表明遗传因素在哮喘发生中起作用，并提示遗传因素可能也会影响儿童哮喘病情的严重程度以及呼吸道感染和体力消耗作为哮喘诱因的影响。
