Tysk C, Lindberg E, Järnerot G, Flodérus-Myrhed B
Department of Medicine, Orebro Medical Center Hospital, Sweden.
Gut. 1988 Jul;29(7):990-6. doi: 10.1136/gut.29.7.990.
By running the Swedish twin registry containing about 25,000 pairs of twins of the same sex together with the central national diagnosis register of hospital inpatients, 80 twin pairs suffering from inflammatory bowel disease were found. In the ulcerative colitis group one of 16 monozygotic pairs was concordant for the disease, but all the other 20 pairs (dizygotic or unknown zygosity) were discordant. In the Crohn's disease group eight of 18 monozygotic pairs and one of 26 dizygotic pairs were concordant. The proband concordance rate among monozygotic twins was 6.3% for ulcerative colitis and 58.3% for Crohn's disease. The calculated heritability of liability based on monozygotic pairs was 0.53 and 1.0 respectively. Thus heredity as an aetiological factor is stronger in Crohn's disease than in ulcerative colitis. Monozygotic twins with Crohn's disease were more likely to be smokers than monozygotic twins with ulcerative colitis. Smoking did not explain the discordance of twin pairs with either ulcerative colitis, or Crohn's disease. The combination of identical heredity and similar smoking habit is not sufficient to cause disease.
通过对瑞典双胞胎登记处（包含约25,000对同性双胞胎）与国家医院住院患者中央诊断登记处的数据进行比对，发现了80对患有炎症性肠病的双胞胎。在溃疡性结肠炎组中，16对同卵双胞胎中有1对患此病，而其他20对（异卵或合子性未知）均不一致。在克罗恩病组中，18对同卵双胞胎中有8对患此病，26对异卵双胞胎中有1对患此病。同卵双胞胎中溃疡性结肠炎的先证者一致率为6.3%，克罗恩病为58.3%。基于同卵双胞胎计算的易感性遗传率分别为0.53和1.0。因此，作为病因因素，遗传在克罗恩病中比在溃疡性结肠炎中更强。患有克罗恩病的同卵双胞胎比患有溃疡性结肠炎的同卵双胞胎更有可能吸烟。吸烟并不能解释患溃疡性结肠炎或克罗恩病的双胞胎对之间的不一致情况。相同的遗传和相似的吸烟习惯不足以导致疾病。
