Restum J C, Bursian S J, Millerick M, Render J A, Merrill A H, Wang E, Rottinghaus G E, Aulerich R J
Department of Animal Science, Michigan State University, East Lansing 48824, USA.
Arch Environ Contam Toxicol. 1995 Nov;29(4):545-50. doi: 10.1007/BF00208387.
Adult female mink (Mustela vison) were fed a diet that contained Fusarium moniliforme culture material that provided dietary concentrations of 89 ppm fumonisin B1, 21 ppm fumonisin B2, and 8 ppm fumonisin B3 for 87 days. During the trial, there was mild lethargy in the mink fed fumonisins, but no other clinical signs or differences in feed consumption (measured during the first two weeks), body weights, or survivability were observed between the fumonisin-treated and control mink. Several hematologic parameters (mean corpuscular hemoglobin concentration, plasma total solids, and lymphocyte concentration) and serum chemical concentrations (globulin, phosphorus, potassium, blood urea nitrogen, creatinine, bilirubin, and cholesterol) and activities (alkaline phosphatase, alanine aminotransferase, amylase, and aspartate aminotransferase) were greater in the mink fed fumonisins than in the controls. Serum albumin/globulin and sodium/potassium ratios and chloride concentrations were lower in the fumonisin-fed mink than in the controls. The concentrations of free sphinganine and the ratio of free sphinganine to free sphingosine in the liver and kidneys of the fumonisin-treated mink were greater than in the control mink. No histopathologic alterations were associated with fumonisin treatment. These results indicate that long-term dietary exposure to F. moniliforme culture material containing 118 ppm total fumonisins is not lethal to adult mink, but can produce adverse physiological effects in the animals.
成年雌性水貂（鼬属）被喂食一种含有串珠镰刀菌培养物的饲料，该饲料中伏马毒素B1的膳食浓度为89 ppm，伏马毒素B2为21 ppm，伏马毒素B3为8 ppm，持续87天。在试验期间，喂食伏马毒素的水貂出现轻度嗜睡，但在伏马毒素处理组和对照组水貂之间未观察到其他临床症状，也未发现饲料消耗（在前两周测量）、体重或存活率有差异。喂食伏马毒素的水貂的几个血液学参数（平均红细胞血红蛋白浓度、血浆总固体和淋巴细胞浓度）以及血清化学物质浓度（球蛋白、磷、钾、血尿素氮、肌酐、胆红素和胆固醇）和活性（碱性磷酸酶、丙氨酸转氨酶、淀粉酶和天冬氨酸转氨酶）均高于对照组。喂食伏马毒素的水貂的血清白蛋白/球蛋白和钠/钾比值以及氯浓度低于对照组。伏马毒素处理组水貂肝脏和肾脏中游离鞘氨醇的浓度以及游离鞘氨醇与游离鞘磷脂的比值高于对照组。未发现与伏马毒素处理相关的组织病理学改变。这些结果表明，长期膳食暴露于含有118 ppm总伏马毒素的串珠镰刀菌培养物对成年水貂无致死性，但可在动物体内产生不良生理影响。
