Kronmiller J E, Nguyen T, Berndt W
Department of Orthodontics, School of Dentistry, Oregon Health Sciences University Portland 97201, USA.
Arch Oral Biol. 1995 Jul;40(7):589-95. doi: 10.1016/0003-9969(95)00014-g.
Endogenous retinoids are present in the embryonic mouse mandible and reach a peak in concentration at the time of the formation of the dental lamina. All-trans retinoic acid is present in a 10-fold higher concentration in the future incisor region of the mouse embryonic mandible at day 11.5. It was found here that exogenous all-trans retinoic acid has pleiotropic effects on the pattern of odontogenesis when applied before the formation of the dental lamina. These effects include a change in the pattern of the dental lamina, supernumerary buds and incisors in the diastema region, and replacement of molars with incisors in the molar region. Thus retinoic acid appears to instruct incisor morphology in the mouse embryonic mandible.
内源性类视黄醇存在于胚胎期小鼠的下颌骨中，并在牙板形成时浓度达到峰值。在胚胎第11.5天，全反式维甲酸在小鼠胚胎下颌骨未来切牙区域的浓度要高10倍。在此研究发现，在牙板形成前应用外源性全反式维甲酸对牙发生模式具有多效性作用。这些作用包括牙板模式改变、间隙区域出现额外的牙蕾和切牙，以及磨牙区域的磨牙被切牙替代。因此，视黄酸似乎在指导小鼠胚胎下颌骨切牙的形态形成。
