Nomura S, Suzuki M, Katsura K, Xie G L, Miyazaki Y, Miyake T, Kido H, Kagawa H, Fukuhara S
First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Atherosclerosis. 1995 Aug;116(2):235-40. doi: 10.1016/0021-9150(95)05551-7.
We investigated the association between low-density lipoprotein (LDL), triglycerides, and platelet activation in 18 patients with hypertension age 41-64 years and 18 with diabetes mellitus aged 43-70 years. Platelet P-selectin positivity and the microparticle level (indicators of activation) were both significantly higher in the diabetics than in healthy controls (P-selectin: 28.0% +/- 7.5% vs. 7.3% +/- 4.2%, P < 0.001; microparticles: 1900 +/- 966 vs. 526 +/- 158/10(4) platelets, P < 0.01). In contrast, there was no significant increase of either parameter in the patients with hypertension. Plasma microparticle levels were also significantly greater in the diabetics with high LDL levels than in those with low LDL levels (2375 +/- 949 vs. 1519 +/- 796/10(4) platelets, P < 0.05), and in those with high rather than low triglyceride levels (2188 +/- 845 vs. 1492 +/- 783/10(4) platelets, P < 0.05). However, platelet positivity for P-selectin was not significantly different between these two subgroups. Microparticle and P-selectin levels both showed no significant difference between the hypertensive patients with high and low LDL or triglyceride levels. These results suggest that platelet-derived microparticles may participate in the development or progression of atherosclerosis in patients with diabetes mellitus.
我们对18名年龄在41 - 64岁的高血压患者和18名年龄在43 - 70岁的糖尿病患者的低密度脂蛋白（LDL）、甘油三酯与血小板活化之间的关联进行了研究。糖尿病患者的血小板P - 选择素阳性率和微粒水平（活化指标）均显著高于健康对照组（P - 选择素：28.0%±7.5% 对比7.3%±4.2%，P < 0.001；微粒：1900±966对比526±158/10⁴血小板，P < 0.01）。相比之下，高血压患者的这两个参数均未显著升高。LDL水平高的糖尿病患者的血浆微粒水平也显著高于LDL水平低的患者（2375±949对比1519±796/10⁴血小板，P < 0.05），甘油三酯水平高的患者高于甘油三酯水平低的患者（2188±845对比1492±783/10⁴血小板，P < 0.05）。然而，这两个亚组之间血小板P - 选择素阳性率没有显著差异。微粒和P - 选择素水平在LDL或甘油三酯水平高和低的高血压患者之间均无显著差异。这些结果表明，血小板衍生的微粒可能参与糖尿病患者动脉粥样硬化的发生或发展。
