Nomura S, Komiyama Y, Miyake T, Miyazaki Y, Kido H, Suzuki M, Kagawa H, Yanabu M, Takahashi H, Fukuhara S
First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Thromb Haemost. 1994 Oct;72(4):519-22.
We investigated the association of amyloid beta-protein precursor (APP) and platelet derived microparticles in 20 normal controls and 91 patients with various diseases causing a thrombotic tendency. Compared with the controls, the mean percentage of APP-positive microparticles was significantly greater in the patients with cerebral infarction (39.1 +/- 17.7%, p < 0.001), diabetes (31.1 +/- 12.6%, p < 0.001), and uremia (30.1 +/- 14.7%, p < 0.01), but not in those with hypertension (8.2 +/- 6.3%, p = NS). Sixteen patients with cerebral infarction, 20 with diabetes, and 11 with uremia had microparticles with very high APP levels. In normal controls, 7.2 +/- 3.7% of the microparticles were positive for P-selectin, while the percentage in cerebral infarction, diabetes, uremia, and hypertension was respectively 43.5 +/- 15.1%, 40.0 +/- 12.8%, 31.8 +/- 12.2%, and 11.6 +/- 7.3%. There was a significant correlation between P-selectin and APP positivity of microparticles. Our results suggest that microparticle APP may have a regulatory influence on coagulation abnormalities.
我们在20名正常对照者和91名患有各种导致血栓形成倾向疾病的患者中，研究了淀粉样β蛋白前体（APP）与血小板衍生微粒之间的关联。与对照组相比，脑梗死患者（39.1±17.7%，p<0.001）、糖尿病患者（31.1±12.6%，p<0.001）和尿毒症患者（30.1±14.7%，p<0.01）中APP阳性微粒的平均百分比显著更高，但高血压患者中则不然（8.2±6.3%，p=无显著性差异）。16名脑梗死患者、20名糖尿病患者和11名尿毒症患者的微粒具有非常高的APP水平。在正常对照者中，7.2±3.7%的微粒P选择素呈阳性，而在脑梗死、糖尿病、尿毒症和高血压患者中的百分比分别为43.5±15.1%、40.0±12.8%、31.8±12.2%和11.6±7.3%。微粒的P选择素与APP阳性之间存在显著相关性。我们的结果表明，微粒APP可能对凝血异常具有调节作用。
