Hauswald M, Ong G, Yeoh E
University of New Mexico School of Medicine, Department of Emergency Medicine, Albuquerque 87131-5246, USA.
Am J Emerg Med. 1995 Nov;13(6):623-5. doi: 10.1016/0735-6757(95)90044-6.
To develop a technique for needle cricothyrotomy that mimics the normal respiratory cycle (using repetitive obstruction of the upper airway and relatively low flow oxygen through small catheters), a controlled trial in three anesthetized dogs was performed. Oxygen from a standard bottle and pressure reducer was delivered through the cricothyroid membrane at 0.36 L/kg/min, which is metabolically equivalent to 0.2 L/kg/min in an adult human. The upper airway was obstructed until the chest rose and then was unobstructed to allow exhalation. The animals were ventilated for 5 minutes to allow equilibration. Arterial PCO2 was measured after 2-minute periods of apnea and 3 minutes of ventilation, each repeated four times. The procedure was repeated in three other dogs at a flow of 0.18 L/kg/min to simulate a 50% air leak. Cricothyroid ventilation at 0.36 L/kg/min lowered the PCO2 from 65 mm Hg to 43 mm Hg, F = 258, P = .004. All PCO2 after 25 minutes were in the normal range. Ventilation at 0.18 L/kg/min stabilized the PCO2 at approximately 1.5 times normal (67 mm Hg versus 79 mm Hg for the preceding apnea, F = 77, P = .013). Flow rates achievable with 18- to 20-gauge catheters and standard oxygen sources are adequate for cricothyroid ventilation when the airway is repetitively obstructed to allow a normal respiratory cycle.
为开发一种模拟正常呼吸周期的环甲膜穿刺通气技术(通过反复阻塞上呼吸道并经小导管给予相对低流量的氧气),对三只麻醉犬进行了一项对照试验。来自标准氧气瓶和减压器的氧气以0.36 L/kg/min的流量通过环甲膜输送,这在代谢上相当于成年人体内的0.2 L/kg/min。阻塞上呼吸道直至胸部隆起,然后解除阻塞以允许呼气。对动物进行5分钟的通气以使其达到平衡。在每次2分钟的呼吸暂停期和3分钟的通气期后测量动脉血二氧化碳分压,每个阶段重复四次。在另外三只犬身上以0.18 L/kg/min的流量重复该操作以模拟50%的漏气情况。以0.36 L/kg/min进行环甲膜通气可使动脉血二氧化碳分压从65 mmHg降至43 mmHg,F = 258,P = 0.004。25分钟后的所有动脉血二氧化碳分压均在正常范围内。以0.18 L/kg/min进行通气可使动脉血二氧化碳分压稳定在正常水平的约1.5倍(呼吸暂停前为67 mmHg,通气时为79 mmHg,F = 77,P = 0.013)。当气道反复阻塞以允许正常呼吸周期时,18至20号导管和标准氧气源所能达到的流量足以进行环甲膜通气。