Buskila D, Berezin M, Gur H, Lin H C, Alosachie I, Terryberry J W, Barka N, Shen B, Peter J B, Shoenfeld Y
Rheumatology Unit, Soroka Medical Center, Ben-Gurion University, Beer-Sheva, Israel.
J Autoimmun. 1995 Jun;8(3):415-24. doi: 10.1006/jaut.1995.0033.
Prolactin (PRL) has been implicated as an important in vivo modulator of cellular and humoral immunity. In order to elucidate the impact of elevated serum PRL levels on the immune system, we measured circulating autoantibodies in the serum of 33 hyperprolactinemic (HPRL) women and in 19 healthy women with normal PRL levels. All sera were examined for the presence of autoantibodies against 15 different antigens, including: ssDNA, dsDNA, histones (H2AH2B), Sm, RNP, SS-A/Ro, SS-B/La, cardiolipin, Scl-70, Jo1, collagen, glomerular basement membrane (GBM), pyruvate dehydrogenase (PDH), proteinase-3 (PR3) and MPO. Twenty-five of 33 (75.7%) HPRL women were found to have at least one autoantibody, while none of the 19 women with normal PRL had any. Eight HPRL women had seven or more (up to nine) different autoantibodies. Some of the autoantibodies were more frequently expressed than others, namely: anti-ss-DNA, anti-dsDNA, anti-Sm, anti-PDH and anti-SS-A/Ro. Autoantibodies to the autoantigens tested are common in a variety of autoimmune and rheumatic disorders including systemic lupus erythematosus (SLE), Sjögren's syndrome, mixed connective tissue disease (MCTD), scleroderma, primary biliary cirrhosis (PBC), polymyositis/dermatomyositis and vasculitis. Yet none of the HPRL women whose serum was found to contain high titers of autoantibodies presented with symptoms related to the respective autoimmune disorders. Our results support the role of PRL in the regulation of immune responses in man.
催乳素（PRL）被认为是细胞免疫和体液免疫的重要体内调节因子。为了阐明血清PRL水平升高对免疫系统的影响，我们检测了33名高催乳素血症（HPRL）女性和19名PRL水平正常的健康女性血清中的循环自身抗体。检测了所有血清中针对15种不同抗原的自身抗体，包括：单链DNA、双链DNA、组蛋白（H2A H2B）、Sm、核糖核蛋白、SS - A/Ro、SS - B/La、心磷脂、Scl - 70、Jo1、胶原蛋白、肾小球基底膜（GBM）、丙酮酸脱氢酶（PDH）、蛋白酶 - 3（PR3）和髓过氧化物酶（MPO）。33名HPRL女性中有25名（75.7%）至少有一种自身抗体，而19名PRL水平正常的女性均未检测到任何自身抗体。8名HPRL女性有7种或更多（最多9种）不同的自身抗体。某些自身抗体的表达比其他抗体更频繁，即：抗单链DNA、抗双链DNA、抗Sm、抗PDH和抗SS - A/Ro。针对所检测自身抗原的自身抗体在多种自身免疫性疾病和风湿性疾病中常见，包括系统性红斑狼疮（SLE）、干燥综合征、混合性结缔组织病（MCTD）、硬皮病、原发性胆汁性肝硬化（PBC）、多发性肌炎/皮肌炎和血管炎。然而，血清中发现含有高滴度自身抗体的HPRL女性均未出现与各自自身免疫性疾病相关的症状。我们的结果支持PRL在人体免疫反应调节中的作用。
