Alcamí A, Smith G L
Sir William Dunn School of Pathology, University of Oxford, UK.
Immunol Today. 1995 Oct;16(10):474-8. doi: 10.1016/0167-5699(95)80030-1.
Poxviruses encode soluble versions of cytokine receptors, which are secreted from the infected cell to block the activity of the cognate cytokine. These viruses offer a unique model system to study the contribution of cytokines to the host response against infection. As discussed here by Antonio Alcamí and Geoffrey Smith, characterization of poxvirus proteins that counteract the immune response may lead to the identification of novel cytokines or cytokine receptors, as well as novel strategies to modulate the inflammatory response.
痘病毒编码细胞因子受体的可溶性形式，这些受体从被感染的细胞中分泌出来，以阻断同源细胞因子的活性。这些病毒提供了一个独特的模型系统，用于研究细胞因子在宿主抗感染反应中的作用。正如安东尼奥·阿尔卡米和杰弗里·史密斯在此所讨论的，对抵抗免疫反应的痘病毒蛋白进行表征，可能会导致鉴定出新的细胞因子或细胞因子受体，以及调节炎症反应的新策略。
