Ferrone S, Marincola F M
Dept of Microbiology and Immunology, New York Medical College, Valhalla 10595, USA.
Immunol Today. 1995 Oct;16(10):487-94. doi: 10.1016/0167-5699(95)80033-6.
Malignant transformation of melanocytes may be associated with changes in the expression of major histocompatibility complex (MHC) HLA class I antigens. Interest in the characterization of abnormalities in the expression of MHC class I by melanoma cells has been rekindled by the current emphasis on the application of T-cell-based immunotherapy to melanoma. Here, Soldano Ferrone and Francesco Marincola review defects in class I expression as described in melanoma cells, as well as the molecular mechanisms, functional significance and clinical implications of such defects.
黑素细胞的恶性转化可能与主要组织相容性复合体（MHC）I类HLA抗原表达的变化有关。目前对基于T细胞的免疫疗法在黑色素瘤中的应用的重视，重新激发了人们对黑色素瘤细胞MHC I类表达异常特征的研究兴趣。在此，索尔达诺·费罗内和弗朗切斯科·马林科拉综述了黑色素瘤细胞中I类表达缺陷的相关研究，以及此类缺陷的分子机制、功能意义和临床意义。
