Silverstein M J, Barth A, Poller D N, Gierson E D, Colburn W J, Waisman J R, Gamagami P
Division of Surgical Oncology, Breast Center, Van Nuys, California 91405, USA.
Eur J Cancer. 1995;31A(9):1425-7. doi: 10.1016/0959-8049(95)00283-o.
The 10-year results of 300 patients with ductal carcinoma in situ (DCIS) without microinvasion are reported; 167 treated with mastectomy and 133 treated with excision and radiation therapy. There was a significant difference in disease-free survival at 10 years, in favour of those treated with mastectomy, 98% versus 81% (P = 0.0004). Multivariate analysis confirmed nuclear grade as the only significant predictor of local recurrence (P = 0.02) or invasive local recurrence (P = 0.03) in patients with DCIS treated with excision and radiation therapy. There was no difference in breast cancer-specific survival or overall survival between the two treatment groups.
报告了300例无微浸润的导管原位癌（DCIS）患者的10年随访结果；其中167例行乳房切除术，133例行切除加放射治疗。10年无病生存率有显著差异，乳房切除术组更具优势，分别为98%和81%（P = 0.0004）。多变量分析证实，对于接受切除加放射治疗的DCIS患者，核分级是局部复发（P = 0.02）或浸润性局部复发（P = 0.03）的唯一显著预测因素。两组治疗组的乳腺癌特异性生存率或总生存率无差异。
