Eskin B A, Grotkowski C E, Connolly C P, Ghent W R
Department of Obstetrics and Gynecology, Medical College of Pennsylvania, Philadelphia 19129, USA.
Biol Trace Elem Res. 1995 Jul;49(1):9-19. doi: 10.1007/BF02788999.
This research describes the effects of short-term elemental iodine (I2) and iodide (I-) replacement on thyroid glands and mammary glands of iodine-deficient (ID) Sprague-Dawley female rats. Iodine deficiency causes atypical tissue and physiologic changes in both glands. Tissue histopathology and the endocrine metabolic parameters, such as serum TT4, tissue and body weights, and vaginal smears, are compared. A moderate reduction in thyroid size from the ID control (IDC) was noted with both I- and I2, whereas serum total thyroxine approached the normal control with both I- and I2, but was lower in IDC. Thyroid gland IDC hyperplasia was reduced modestly with I2, but eliminated with I-. Lobular hyperplasia of the mammary glands decreased with I2 and increased with I- when compared with the IDC; extraductal secretions remained the same as IDC with I2, but increased with I-; and periductal fibrosis was markedly reduced with I2, but remained severe with I-. Thus, orally administered I2 or I- in trace doses with similar iodine availability caused different histopathological and endocrine patterns in thyroid and mammary glands of ID rats. The significance of this is that replacement therapy with various forms of iodine are tissue-specific.
本研究描述了短期补充元素碘（I₂）和碘化物（I⁻）对碘缺乏（ID）的斯普拉格-道利雌性大鼠甲状腺和乳腺的影响。碘缺乏会导致这两种腺体出现非典型的组织和生理变化。对组织组织病理学以及内分泌代谢参数进行了比较，这些参数包括血清总甲状腺素（TT4）、组织和体重以及阴道涂片。与碘缺乏对照组（IDC）相比，I⁻和I₂均使甲状腺大小适度减小，而I⁻和I₂均使血清总甲状腺素接近正常对照组，但在IDC中较低。I₂使甲状腺IDC增生略有减轻，但I⁻使其消除。与IDC相比，I₂使乳腺小叶增生减少，I⁻使其增加；I₂使导管外分泌物与IDC保持相同，但I⁻使其增加；I₂使导管周围纤维化明显减轻，但I⁻使其仍很严重。因此，口服微量的I₂或I⁻，在碘可利用性相似的情况下，会在ID大鼠的甲状腺和乳腺中引起不同的组织病理学和内分泌模式。其意义在于，用各种形式的碘进行替代疗法具有组织特异性。
