Malya Fatma Umit, Kadioglu Huseyin, Hasbahceci Mustafa, Dolay Kemal, Guzel Mehmet, Ersoy Yeliz Emine
Department of General Surgery, 221266 Bezmialem Vakif University Faculty of Medicine , Istanbul, Turkey.
J Int Med Res. 2018 Feb;46(2):687-692. doi: 10.1177/0300060517717535. Epub 2017 Aug 31.
Objective To compare urinary iodine excretion levels in patients with breast cancer and control subjects. Methods In this prospective pilot study, patients with breast cancer and normal controls were recruited. Age and menopausal status were recorded. Levels of serum thyroid-stimulating hormone, blood urea nitrogen and creatinine and urine iodine concentration (UIC) were measured. UIC levels were divided into three categories: low (<100 µg/l), normal (100-200 µg/l) or high (>200 µg/l). Results A total of 24 patients with breast cancer and 48 controls were included in the study. There were no statistically significant differences between the two groups with regard to thyroid-stimulating hormone, blood urea nitrogen or creatinine levels. When considered overall, there was no statistical difference in UIC between patients and controls. However, comparisons within each category (low, normal or high UIC) showed a significantly higher percentage of patients with breast cancer had a high UIC compared with controls. Conclusions A high UIC was seen in a significantly higher percentage of patients with breast cancer than controls. UIC may have a role as a marker for breast cancer screening. Further studies evaluating UIC and iodine utilization in patients with breast cancer are warranted.
目的 比较乳腺癌患者与对照人群的尿碘排泄水平。方法 在这项前瞻性试点研究中，招募了乳腺癌患者和正常对照者。记录年龄和绝经状态。测量血清促甲状腺激素、血尿素氮、肌酐水平以及尿碘浓度（UIC）。UIC水平分为三类：低（<100μg/l）、正常（100 - 200μg/l）或高（>200μg/l）。结果 本研究共纳入24例乳腺癌患者和48例对照者。两组在促甲状腺激素、血尿素氮或肌酐水平方面无统计学显著差异。总体来看，患者与对照者的UIC无统计学差异。然而，在每个类别（低、正常或高UIC）内进行比较时，乳腺癌患者中UIC高的比例显著高于对照者。结论 乳腺癌患者中UIC高的比例显著高于对照者。UIC可能作为乳腺癌筛查的一个标志物。有必要进一步开展评估乳腺癌患者UIC及碘利用情况的研究。
