Issaragrisil S, Kaufman D W, Anderson T E, Chansung K, Thamprasit T, Sirijirachai J, Piankijagum A, Porapakham Y, Vannasaeng S, Leaverton P E
Department of Medicine, Faculty of Medicine, Siriraj Hospital, Bangkok, Thailand.
Br J Haematol. 1995 Sep;91(1):80-4. doi: 10.1111/j.1365-2141.1995.tb05248.x.
The relationship of socioeconomic status to the risk of aplastic anaemia was evaluated in a case-control study conducted in Bangkok and two rural regions of Thailand (Khonkaen and Songkla). Among 152 cases and 921 controls there were significant trends of increasing risk with decreasing years of education (P = 0.01) and total household income (P = 0.0001), after control for confounding. The relative risk estimate for those with monthly incomes of < 1500 baht (about $60 U.S.) was 3.9 (95% confidence interval 2.1-7.3) compared to those with monthly incomes of at least 5000 baht (about $200). The pattern of increasing risk with decreasing income was observed in all three regions, with significant trends in Bangkok (P = 0.004) and Khonkaen (P = 0.003). This finding may partly explain the high incidence of aplastic anaemia in Thailand. Low socioeconomic status may be a surrogate for one or more environmental factors that could cause aplastic anaemia, such as infectious pathogens or toxic exposures.
在曼谷以及泰国的两个农村地区（孔敬和宋卡）开展的一项病例对照研究中，对社会经济地位与再生障碍性贫血风险之间的关系进行了评估。在152例病例和921名对照中，在控制混杂因素后，随着受教育年限的减少（P = 0.01）和家庭总收入的降低（P = 0.0001），风险呈显著增加趋势。月收入低于1500泰铢（约60美元）的人群与月收入至少5000泰铢（约200美元）的人群相比，相对风险估计值为3.9（95%置信区间2.1 - 7.3）。在所有三个地区均观察到风险随收入降低而增加的模式，在曼谷（P = 0.004）和孔敬（P = 0.003）有显著趋势。这一发现可能部分解释了泰国再生障碍性贫血的高发病率。社会经济地位低可能是一种或多种可导致再生障碍性贫血的环境因素的替代指标，如感染性病原体或有毒暴露。
