Issaragrisil S, Sriratanasatavorn C, Piankijagum A, Vannasaeng S, Porapakkham Y, Leaverton P E, Kaufman D W, Anderson T E, Shapiro S, Young N S
Department of Medicine, Faculty of Medicine, Siriraj Hospital, Bangkok, Thailand.
Blood. 1991 May 15;77(10):2166-8.
The annual incidence of aplastic anemia in metropolitan Bangkok, Thailand, and its five suburban provinces was prospectively determined. All patients first diagnosed during the period from January through December 1989 who met specific clinical and pathologic criteria were included. Thirty-two cases were identified, yielding an overall incidence of 3.7 per million. The incidence rates for the age groups 0 through 24, 25 through 59, and over 60 years were 4.3, 3.2, and 2.1 per million, respectively; the highest rate, 7.2 per million, was found for individuals aged 15 to 24 years. The male-to-female ratio was 1.9. The incidence of aplastic anemia in Bangkok is higher than that reported in recent European studies. The peak rate in young persons is almost fourfold higher than in comparable recent western studies and suggests an environmental etiology peculiar to Thailand.
对泰国曼谷及其五个郊区省份再生障碍性贫血的年发病率进行了前瞻性测定。纳入了1989年1月至12月期间首次诊断出的所有符合特定临床和病理标准的患者。共确诊32例，总发病率为百万分之3.7。0至24岁、25至59岁以及60岁以上年龄组的发病率分别为百万分之4.3、3.2和2.1；15至24岁个体的发病率最高，为百万分之7.2。男女比例为1.9。曼谷再生障碍性贫血的发病率高于近期欧洲研究报告的发病率。年轻人中的发病率峰值几乎是近期西方类似研究的四倍，提示泰国存在特殊的环境病因。
