Issaragrisil S, Kaufman D W, Anderson T
Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Eur J Haematol Suppl. 1996;60:31-4. doi: 10.1111/j.1600-0609.1996.tb01642.x.
A population-based, case-control study of aplastic anaemia has been conducted in Thailand since 1989. Up to December 1994, the overall annual incidence was 3.9/10(6) in Bangkok, 5.0/10(6) in Khonkaen and 3.0/10(6) in Songkla. In Bangkok, the incidence peaked in 2 age groups (at 15-24 yr and > or = 60 yr), whereas in Khonkaen and Songkla there was a consistent increase in incidence with increasing age. The results of case-control analyses for non-drug risk factors indicate a strong inverse association with socio-economic status present in all 3 areas; a strong association with grain farming in the 2 rural areas that does not appear to be explained by pesticides; an association with occupational exposure to solvents in Bangkok; and a positive association with hepatitis A seropositivity.
自1989年以来，泰国开展了一项基于人群的再生障碍性贫血病例对照研究。截至1994年12月，曼谷的年总发病率为3.9/10⁶，孔敬为5.0/10⁶，宋卡为3.0/10⁶。在曼谷，发病率在两个年龄组达到峰值（15 - 24岁和≥60岁），而在孔敬和宋卡，发病率随年龄增长持续上升。非药物风险因素的病例对照分析结果表明，在所有三个地区，发病率与社会经济地位呈强烈负相关；在两个农村地区，发病率与谷物种植呈强烈相关，这似乎无法用接触杀虫剂来解释；在曼谷，发病率与职业接触溶剂有关；发病率与甲型肝炎血清阳性呈正相关。
