从小鼠肾脏中克隆25-羟基维生素D-3 24-羟化酶（Cyp-24）：其受维生素D-3的诱导作用
Molecular cloning of 25-hydroxyvitamin D-3 24-hydroxylase (Cyp-24) from mouse kidney: its inducibility by vitamin D-3.
作者信息
Itoh S, Yoshimura T, Iemura O, Yamada E, Tsujikawa K, Kohama Y, Mimura T
机构信息
Division of Bio-Medical and Immunological Chemistry, Faculty of Pharmaceutical Sciences, Osaka University, Japan.
出版信息
Biochim Biophys Acta. 1995 Oct 17;1264(1):26-8. doi: 10.1016/0167-4781(95)00147-9.
A cDNA encoding a 25-hydroxyvitamin D-3 24-hydroxylase, Cyp-24, has been isolated from mouse kidney cDNA library by hybridization screening. Mouse Cyp-24, coding for 514 amino acid residues, shared 82.1 and 94.7% amino acid identity with human and rat CYP24s, respectively. Among mouse organs examined, Cyp-24 mRNA could be detected in the kidney. When mice were treated with vitamin D-3, Cyp-24 mRNA was induced in the kidney.
通过杂交筛选从小鼠肾脏cDNA文库中分离出一种编码25-羟基维生素D-3 24-羟化酶（Cyp-24）的cDNA。小鼠Cyp-24编码514个氨基酸残基，与人及大鼠的CYP24分别具有82.1%和94.7%的氨基酸同一性。在所检测的小鼠器官中，肾脏中可检测到Cyp-24 mRNA。用维生素D-3处理小鼠后，肾脏中Cyp-24 mRNA被诱导表达。
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