Liddle P F
Department of Psychiatry, University of British Columbia, Vancouver, Canada.
Eur Arch Psychiatry Clin Neurosci. 1995;245(4-5):210-5. doi: 10.1007/BF02191799.
Kraepelin's conclusion that there were underlying common features justifying the amalgamation of catatonia, hebephrenia and paranoia hallucinatoria to form a single illness is confirmed by factor analytic studies delineating the various dimensions of schizophrenic psychopathology. Neuropsychological studies reveal that the three cardinal dimensions reflect disorder of the supervisory mental processes responsible for initiation, selection and monitoring of self-generated mental activity. Brain-imaging studies indicate that the underlying neuropathology entails disordered functional connectivity within the neural networks in multimodal association cortex that are the substrate of the supervisory mental processes, consistent with Kraepelin's own speculation about the essential nature of the condition.
克雷佩林得出结论，认为紧张症、青春型精神分裂症和幻觉型偏执狂存在潜在的共同特征，足以将它们合并为一种单一疾病，这一结论得到了对精神分裂症心理病理学各维度进行描述的因素分析研究的证实。神经心理学研究表明，这三个主要维度反映了负责启动、选择和监测自我产生的心理活动的监督性心理过程的紊乱。脑成像研究表明，潜在的神经病理学涉及多模态联合皮层神经网络内功能连接紊乱，而这些神经网络是监督性心理过程的基础，这与克雷佩林自己对该病症本质的推测一致。
