Ricci G, D'Ambrosi A, Resca D, Masotti M, Alvisi V
Institute of Internal Medicine I, Postgraduate School of Gastroenterology and Endoscopy, University of Ferrara, Italy.
Biomed Pharmacother. 1995;49(5):259-62. doi: 10.1016/0753-3322(96)82632-1.
Total sialic acid (TSA), C-reactive protein (CRP); alpha 1 acid glycoprotein (alpha 1-AG), and beta 2-microglobulin were determined in 84 patients affected by non-malignant intestinal diseases, Crohn's disease (CD) and ulcerative colitis (UC), active and in remission; non-ulcerative proctosigmoiditis; diverticulosis; diverticulitis (ie, inflammatory complication of diverticulosis). Only in patients with acute phase CD, TSA was statistically higher than those in remission, as well as in controls. In patients with acute CD and in those with diverticulitis, CRP was significantly higher than in the controls. alpha 1-AG was found significantly increased in acute UC and CD patients versus the respective groups in remission, as well as versus controls. Moreover, alpha 1-AG was higher in patients with diverticulitis. beta 2-microglobulin did not differ in any group of patients. In five patients with CD in acute phase, investigated before and during the pharmacological treatment (5-aminosalycilic acid and steroids), CRP values fell into the normal range after the second week of therapy, whereas TSA values reached the higher limit of the normal range after the third week, except for two CD patients with a larger location (ileocolonic) of the disease. The results are briefly discussed.
在84例患有非恶性肠道疾病的患者中测定了总唾液酸（TSA）、C反应蛋白（CRP）、α1酸性糖蛋白（α1-AG）和β2微球蛋白，这些疾病包括克罗恩病（CD）和溃疡性结肠炎（UC），处于活动期和缓解期；非溃疡性直肠乙状结肠炎；憩室病；憩室炎（即憩室病的炎症并发症）。仅在急性期CD患者中，TSA在统计学上高于缓解期患者以及对照组。在急性CD患者和憩室炎患者中，CRP显著高于对照组。与各自缓解期的组以及对照组相比，急性UC和CD患者的α1-AG显著升高。此外，憩室炎患者的α1-AG更高。β2微球蛋白在任何一组患者中均无差异。在5例急性期CD患者中，在药物治疗（5-氨基水杨酸和类固醇）之前和期间进行了研究，治疗第二周后CRP值降至正常范围，而除2例病变部位较大（回结肠）的CD患者外，TSA值在第三周达到正常范围的上限。对结果进行了简要讨论。
