Campbell C A, Walker-Smith J A, Hindocha P, Adinolfi M
J Pediatr Gastroenterol Nutr. 1982;1(2):193-200. doi: 10.1097/00005176-198201020-00007.
The serum levels of five acute phase proteins (APP) were measured in 18 children with Crohn's Disease (CD) or ulcerative colitis (UC) and in two control groups. The levels of C-reactive protein, alpha 1-acid glycoprotein, alpha 1-antitrypsin, C9, and Factor B were significantly raised in patients with CD and UC with good separation from controls, but they were not entirely reliable used as screening tests unless used in combination. The levels of APP were monitored for periods varying from 18 to 28 months in each patient and found to reflect the disease activity in both CD and UC. On seven occasions the APP levels did not match the clinically assessed disease activity, but when the serum levels were related to outcome of the disease, C-reactive protein was found to be elevated--whether or not there were symptoms of the disease--in all patients who later had a relapse, while normal values were found in those who had a long remission. These results suggest that the estimation of Creative protein is of prognostic value and that its measurement is particularly useful in children with mild symptoms in whom disease activity and prognosis are difficult to assess.
在18名患有克罗恩病（CD）或溃疡性结肠炎（UC）的儿童以及两个对照组中测量了5种急性期蛋白（APP）的血清水平。CD和UC患者的C反应蛋白、α1-酸性糖蛋白、α1-抗胰蛋白酶、C9和B因子水平显著升高，与对照组有明显差异，但除非联合使用，否则它们作为筛查试验并不完全可靠。对每位患者进行了18至28个月不等的APP水平监测，发现其反映了CD和UC的疾病活动情况。有7次APP水平与临床评估的疾病活动情况不相符，但当血清水平与疾病转归相关时，发现所有后来复发的患者C反应蛋白均升高——无论是否有疾病症状——而病情长期缓解的患者C反应蛋白值正常。这些结果表明，C反应蛋白的评估具有预后价值，其测量对症状较轻、疾病活动和预后难以评估的儿童尤为有用。
