Macfarlane P I, Miller V, Wells F, Richards B
J Pediatr Gastroenterol Nutr. 1986 Jan;5(1):93-6. doi: 10.1097/00005176-198601000-00017.
The erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and serum orosomucoid were measured in children with Crohn's disease and ulcerative colitis in various states of disease activity. Results were matched with a clinical assessment to determine the correlation between laboratory test values and disease activity. Regression analysis showed that serum orosomucoid reflected disease activity better than ESR in both diseases. Orosomucoid but not ESR discriminated between disease in remission and mild disease in ulcerative colitis. No test invariably predicted presence or absence of active disease. Orosomucoid and ESR were complementary, but CRP was of no additional value. The usefulness of orosomucoid and ESR as objective measures of inflammatory activity was not masked by corticosteroid medication.
在处于不同疾病活动状态的克罗恩病和溃疡性结肠炎患儿中，检测了红细胞沉降率（ESR）、C反应蛋白（CRP）和血清类粘蛋白。将结果与临床评估进行匹配，以确定实验室检测值与疾病活动之间的相关性。回归分析表明，在这两种疾病中，血清类粘蛋白比ESR能更好地反映疾病活动。在溃疡性结肠炎中，类粘蛋白而非ESR能区分缓解期疾病和轻度疾病。没有一项检测能始终如一地预测疾病是否处于活动期。类粘蛋白和ESR具有互补性，但CRP并无额外价值。类粘蛋白和ESR作为炎症活动客观指标的有用性并未被皮质类固醇药物所掩盖。
