Pontiggia P, Bianchi Santamaria A, Alonso K, Santamaria L
C Golgi Institute of General Pathology, Centro Tumori, University of Pavia, Italy.
Biomed Pharmacother. 1995;49(5):263-5. doi: 10.1016/0753-3322(96)82633-3.
The objective of this work was to check possible additive beneficial effects of whole body hyperthermia (WBH) associated with beta-carotene (BC) supplementation in patients with AIDS. In a pilot study, 10 HIV positive patients, (8 with AIDS and 2 with AIDS related complex, ARC), after AZT or DDI discontinuation, were first treated with one single session of WBH applied with a non-invasive procedure at 42 degrees C core temperature for one hour, and subsequently supplemented with BC 120 mg daily continuously. All patients well tolerated the non-invasive WBH as well as the high dose BC supplementation. Apart from one patient who died after 4 months, all the others underwent an HIV burden diminution, clinical improvement and amelioration of laboratory data, along with an subjective improvement of their life quality. With reference to control groups, namely (a) only WBH applied with extracorporeal procedure to 31 AIDS patients, and (b) only BC supplementation at high dosage applied to 64 ARC patients, the combined physical and BC supplemental treatments clearly showed a better and longer lasting response.
这项工作的目的是检验全身热疗（WBH）联合补充β-胡萝卜素（BC）对艾滋病患者可能产生的附加有益效果。在一项初步研究中，10名HIV阳性患者（8名艾滋病患者和2名艾滋病相关综合征患者）在停用齐多夫定（AZT）或双脱氧肌苷（DDI）后，首先接受了一次非侵入性全身热疗，核心温度为42摄氏度，持续1小时，随后持续每日补充120毫克β-胡萝卜素。所有患者对非侵入性全身热疗以及高剂量β-胡萝卜素补充均耐受良好。除1名患者在4个月后死亡外，其他所有患者的HIV负担均减轻，临床症状改善，实验室数据好转，生活质量也有主观改善。与对照组相比，即（a）仅对31名艾滋病患者采用体外方法进行全身热疗，以及（b）仅对64名艾滋病相关综合征患者进行高剂量β-胡萝卜素补充，物理治疗与β-胡萝卜素补充联合治疗明显显示出更好且更持久的效果。
