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简短通讯:β-胡萝卜素在艾滋病相关综合征患者中的可能作用。一项初步研究。

Short communication: possible activity of beta-carotene in patients with the AIDS related complex. A pilot study.

作者信息

Bianchi-Santamaria A, Fedeli S, Santamaria L

机构信息

Camillo Golgi Institute of General Pathology, Centro Tumori, University of Pavia, Italy.

出版信息

Med Oncol Tumor Pharmacother. 1992;9(3):151-3. doi: 10.1007/BF02987747.

Abstract

In a pilot single blind study, beta-carotene (BC) supplementation produced, in ARC patients under current treatment, apparent recovery from asthenia, fever, nocturnal sweating, diarrhoea, loss in weight, and led as a result to an improvement in general health and working efficiency, but not to an improvement in multiple district lympho-adenopathies. Nevertheless, BC appeared to prevent progress to AIDS and, in addition, to lower the effective dosage of AZT used in one case of ARC developed into AIDS, producing a recovery from opportunistic infections and an inhibition of Kaposi sarcoma diffusion, in line with a two-fold rise in CD4 counts.

摘要

在一项初步单盲研究中,对接受当前治疗的艾滋病相关综合征(ARC)患者补充β-胡萝卜素(BC)后,患者的乏力、发热、盗汗、腹泻、体重减轻等症状明显恢复,总体健康状况和工作效率也因此得到改善,但多处淋巴结病未见好转。然而,BC似乎可预防病情发展为艾滋病,此外,对于一名发展为艾滋病的ARC患者,BC还降低了所用齐多夫定(AZT)的有效剂量,使机会性感染得以恢复,并抑制了卡波西肉瘤的扩散,同时CD4细胞计数增加了两倍。

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