Godin I, Dieterlen-Lièvre F, Cumano A
Institut d'Embryologie Cellulaire et Moléculaire, CNRS, Nogent Sur Marne, France.
Semin Immunol. 1995 Jun;7(3):131-41. doi: 10.1016/1044-5323(95)90041-1.
Increasing interest in the initial steps of hemopoiesis in the embryo is prompted by the lack of information about the primordial origin and the nature of hemopoietic stem cells. It appears critical to understand the emergence, diversification and differentiation potential of hemopoietic cells in the preliver embryo. In-vitro studies of B-potential in the mouse embryo prior to liver colonization show that, contrary to interpretations prevalent 10 years ago, there are two sources of B-cell progenitors (and most probably stem cells) at these stages: the yolk sac and the paraaortic splanchnopleura within the embryo proper. The analysis of the phenotype and differentiation potential of precursors from both sources shows them to be very similar, while different from the fetal liver progenitors. Indications for an independent generation of precursors in both sites are reviewed.
由于缺乏关于造血干细胞的原始起源和性质的信息，人们对胚胎造血初始阶段的兴趣与日俱增。了解肝前胚胎中造血细胞的出现、多样化和分化潜能显得至关重要。对小鼠胚胎在肝脏定植前的B细胞潜能进行的体外研究表明，与10年前流行的解释相反，在这些阶段有两个B细胞祖细胞（很可能还有干细胞）来源：卵黄囊和胚胎本身内的主动脉旁脏壁中胚层。对来自这两个来源的前体细胞的表型和分化潜能分析表明，它们非常相似，而与胎儿肝脏祖细胞不同。本文综述了两个部位前体细胞独立产生的证据。
