Kee B L, Paige C J
Wellesley Hospital Research Institute, University of Toronto, Canada.
Semin Immunol. 1995 Jun;7(3):143-54. doi: 10.1016/1044-5323(95)90042-x.
The development of mature B lymphocytes from multipotent progenitors follows a pathway of differentiation marked by a progressive restriction in lineage options. The requirements for progression through the B lineage developmental pathway have been investigated intensively and a number of critical components of the differentiation process have been identified. However, the genetic basis for lineage determination remains unresolved. Recently, a number of in-vitro assays have been established which support the development of committed B cell progenitors from multipotent cells. These assays have provided a novel system in which the process of B lineage commitment can be followed and manipulated. In this review we present a model of B-lineage progression from multipotent progenitors to committed B-cell progenitors and discuss potential mediators of the commitment process.
多能祖细胞发育为成熟B淋巴细胞遵循一条分化途径，其特征是谱系选择逐渐受到限制。人们对通过B谱系发育途径的进展要求进行了深入研究，并确定了分化过程中的一些关键成分。然而，谱系确定的遗传基础仍未得到解决。最近，已经建立了一些体外试验，这些试验支持从多能细胞发育为定向B细胞祖细胞。这些试验提供了一个新的系统，在这个系统中可以追踪和操纵B谱系定向过程。在这篇综述中，我们提出了一个从多能祖细胞到定向B细胞祖细胞的B谱系进展模型，并讨论了定向过程的潜在介导因子。
