Farrar D J, Locke S E, Kantrowitz F G
Department of Psychiatry, Beth Israel Hospital, Harvard Medical School, Boston, USA.
Behav Med. 1995 Spring;21(1):5-16. doi: 10.1080/08964289.1995.9933737.
Chronic fatigue syndrome (CFS) is a disorder of unknown etiology characterized by debilitating fatigue and other somatic and neuropsychiatric symptoms. A range of heterogeneous clinical and laboratory findings have been reported in patients with CFS. Various theories have been proposed to explain the underlying pathophysiologic processes but none has been proved. Research findings of immunologic dysfunction and neuroendocrine changes suggest the possible dysregulation of interactions between the nervous system and the immune system. Without a clear understanding of its etiopathogenesis, CFS has no definitive treatment. Management approaches have been necessarily speculative, and they have evolved separately in a number of medical and nonmedical disciplines. The results of several controlled treatment studies have been inconclusive. An accurate case definition identifying homogeneous subtypes of CFS is needed. The integration of medical and psychologic treatment modalities and the use of both biologic and psychologic markers to evaluate treatment response will enhance future treatment strategies.
慢性疲劳综合征（CFS）是一种病因不明的疾病，其特征为使人衰弱的疲劳以及其他躯体和神经精神症状。CFS患者已报告有一系列异质性的临床和实验室检查结果。已提出各种理论来解释潜在的病理生理过程，但均未得到证实。免疫功能障碍和神经内分泌变化的研究结果提示，神经系统与免疫系统之间的相互作用可能失调。由于对其病因发病机制尚无清晰认识，CFS没有确切的治疗方法。管理方法必然具有推测性，并且在多个医学和非医学学科中各自发展。多项对照治疗研究的结果尚无定论。需要一个准确的病例定义来识别CFS的同质亚型。整合医学和心理治疗方式以及使用生物学和心理学标志物来评估治疗反应将增强未来的治疗策略。
