Mantovani A, Ricciardi C, Stazi A V, Macrì C
Laboratorio di Tossicologia Comparata ed Ecotossicologia, Istituto Superiore di Sanità, Rome, Italy.
Reprod Toxicol. 1995 May-Jun;9(3):265-73. doi: 10.1016/0890-6238(95)00008-x.
Albendazole (ABZ) was utilized as a model to investigate the pathogenesis of benzimidazole-induced abnormalities. Pregnant Sprague-Dawley rats were treated po with 0, 10, 20, and 30 mg/kg on gestational days (GD) 10 to 12. The embryos were examined on GD 13, as a window for observing the origin of alterations detected at term. Embryolethality and growth reduction showed dose-related increases at the three dose levels. At 10 mg/kg, an increased developmental delay of limb buds and a less than 5% incidence of embryos with abnormal head or shape were detected. At 20 and 30 mg/kg, > 20% of embryos showed morphologic alterations involving mainly shape abnormalities and the development of forelimb buds, branchial bars, eye, and telencephalon; closure of neuropores was unaffected. Dose-response relationships for morphologic alterations showed steeper slopes than for growth reduction and embryolethality.
阿苯达唑（ABZ）被用作模型来研究苯并咪唑诱导异常的发病机制。在妊娠第10至12天，对怀孕的斯普拉格-道利大鼠经口给予0、10、20和30mg/kg的剂量。在妊娠第13天检查胚胎，作为观察足月时检测到的改变起源的窗口。在三个剂量水平下，胚胎致死率和生长抑制呈剂量相关增加。在10mg/kg时，检测到肢芽发育延迟增加，头部或形状异常的胚胎发生率低于5%。在20和30mg/kg时，>20%的胚胎出现形态学改变，主要涉及形状异常以及前肢芽、鳃弓、眼睛和端脑的发育；神经孔闭合未受影响。形态学改变的剂量反应关系比生长抑制和胚胎致死率的斜率更陡。
