Tanaka T
Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Japan.
Reprod Toxicol. 1995 May-Jun;9(3):281-8. doi: 10.1016/0890-6238(95)00010-8.
The fungicide imazalil was given in the diet at levels of 0 (control), 0.012, 0.024, and 0.048% from 5 weeks of age of the F0 generation to 9 weeks of age in the F1 generation in mice, and selected reproductive and neurobehavioral parameters were measured. Number of movements, movement time, total distance, number of vertical activities, number of turnings, and number of defecations during movement activity at 8 weeks of age of the F0 generation showed adverse effects of treatment on male mice. There were few adverse effects of imazalil on either litter size or weight and sex ratio. Average body weight of offspring during the early lactation period was significantly depressed in the high- and middle-dose groups of each sex. In the neurobehavioral parameters, surface righting and swimming head angle were significantly affected in male and female offspring during the early lactation period. The dose levels of imazalil in this study produced some adverse effects in reproductive and neurobehavioral parameters in mice.
在小鼠中，从F0代5周龄至F1代9周龄期间，在饮食中添加浓度为0（对照）、0.012%、0.024%和0.048%的杀菌剂抑霉唑，并测量选定的生殖和神经行为参数。F0代8周龄时，运动活动期间的运动次数、运动时间、总距离、垂直活动次数、转弯次数和排便次数显示，处理对雄性小鼠有不良影响。抑霉唑对产仔数、体重和性别比例几乎没有不良影响。各性别的高剂量和中剂量组中，哺乳期早期后代的平均体重显著降低。在神经行为参数方面，哺乳期早期雄性和雌性后代的表面翻正和游泳头角受到显著影响。本研究中抑霉唑的剂量水平对小鼠的生殖和神经行为参数产生了一些不良影响。
