Porcu E, Filicori M, Dal Prato L, Fabbri R, Seracchioli R, Colombi C, Flamigni C
Reproductive Medicine Unit, University of Bologna, Italy.
J Assist Reprod Genet. 1995 Jan;12(1):15-9. doi: 10.1007/BF02214123.
To compare the effects of depot and daily forms of GnRH analogs in IVF programs.
One hundred seventeen patients undergoing IVF, with no severe male factor, were randomized between two treatment groups. Pituitary desensitization was obtained in group 1 (60 patients) with a single IM injection of leuprorelin (3.75 mg), and in group 2 (57 patients) with buserelin (0.3 mg SC twice daily). In a subgroup of 10 patients (5 for the depot form and 5 for the daily form) several GnRH tests were performed to investigate pituitary desensitization.
No differences were found in the time to reach desensitization. Resumption of pituitary activity occurred in 7 days with the daily form and in about 2 months with the depot form. No significant differences were found in the stimulation pattern, oocyte quality, percentage of fertilization. The pregnancy rate per transfer was slightly, but not significantly, better in the depot group (29.4% vs 25.9%). Implantation rate (11.9% vs 12.3%) and the percentage of miscarriages (26.6% vs 28.5%) were similar.
Depot and daily forms of GnRH analogs are equally effective in superovulation induction for IVF. Considering improved patient compliance and preference, depot forms are advantageous.
比较长效和每日使用剂型的促性腺激素释放激素（GnRH）类似物在体外受精（IVF）方案中的效果。
117例接受IVF且无严重男性因素的患者被随机分为两个治疗组。第1组（60例患者）通过单次肌内注射亮丙瑞林（3.75mg）实现垂体脱敏，第2组（57例患者）通过皮下注射布舍瑞林（0.3mg，每日两次）实现垂体脱敏。在10例患者的亚组中（长效剂型5例，每日剂型5例）进行了多项GnRH测试以研究垂体脱敏情况。
在达到脱敏所需时间上未发现差异。每日剂型在7天恢复垂体活性，长效剂型在约2个月恢复垂体活性。在刺激模式、卵母细胞质量、受精率方面未发现显著差异。长效剂型组每次移植的妊娠率略高，但无显著差异（29.4%对25.9%）。着床率（11.9%对12.3%）和流产率（26.6%对28.5%）相似。
长效和每日使用剂型的GnRH类似物在IVF超排卵诱导中同样有效。考虑到患者依从性和偏好的改善，长效剂型更具优势。
