Sopelak V M, Hodgen G D
Am J Obstet Gynecol. 1987 Mar;156(3):755-60. doi: 10.1016/0002-9378(87)90092-5.
To determine whether a gonadotropin-releasing hormone agonist could cross the placenta to the fetus, each pregnant rhesus monkey (110 to 155 days' gestation, n = 10) and her in utero fetus had indwelling cannulas placed in the femoral veins. Gonadotropin-releasing hormone agonist (1000 micrograms intravenously) was injected into the mother (n = 8) or fetus (n = 2); serial blood samples were collected from mother and fetus for luteinizing hormone and follicle-stimulating hormone determination. None of the mothers responded to the gonadotropin-releasing hormone agonist bolus. In contrast, some of the fetal monkeys receiving gonadotropin-releasing hormone agonist via placental transfer and all fetal monkeys injected directly with the agonist responded as indicated by increased luteinizing hormone (2.8- to 12.3-fold) and follicle-stimulating hormone (1.5- to 8.9-fold) concentrations. In evaluating maternal and fetal effects, we found that continuous maternal infusion with either gonadotropin-releasing hormone agonist (n = 14) or saline solution (n = 11) throughout pregnancy did not alter maternal hormonal profiles. Histologically, gonads from their infants, removed within 3 days post partum, were normal. Although neonatal ovarian weights were unaffected by the in utero treatment, the testes weighed less (p less than 0.05) in male infants born of mothers treated with gonadotropin-releasing hormone agonist compared to controls. Thus gonadotropin-releasing hormone agonist can cross from maternal to fetal circulation, and the fetus can respond (at least during the third trimester).
为了确定促性腺激素释放激素激动剂是否能穿过胎盘作用于胎儿，给每只怀孕的恒河猴（孕期110至155天，n = 10）及其子宫内的胎儿在股静脉留置套管。向母亲（n = 8）或胎儿（n = 2）静脉注射促性腺激素释放激素激动剂（1000微克）；从母亲和胎儿采集系列血样以测定黄体生成素和卵泡刺激素。母亲对促性腺激素释放激素激动剂推注均无反应。相比之下，一些经胎盘转运接受促性腺激素释放激素激动剂的胎猴以及所有直接注射该激动剂的胎猴，其黄体生成素（升高2.8至12.3倍）和卵泡刺激素（升高1.5至8.9倍）浓度升高，表明有反应。在评估对母亲和胎儿的影响时，我们发现整个孕期持续给母亲输注促性腺激素释放激素激动剂（n = 14）或生理盐水（n = 11）均未改变母亲的激素水平。组织学检查显示，产后3天内取出的婴儿性腺正常。虽然宫内治疗对新生儿卵巢重量无影响，但与对照组相比，接受促性腺激素释放激素激动剂治疗的母亲所生男婴的睾丸重量较轻（p < 0.05）。因此，促性腺激素释放激素激动剂可从母体循环进入胎儿循环，且胎儿能够产生反应（至少在孕晚期）。
