Fang C L, Zong W J, Fan G R
Subei People Hospital, Yangzhou Medical College, Jiangsu.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995 Jul;15(7):405-7.
Fifty-six cases with lung carcinoma were detected for peripheral blood T lymphocyte by direct staphylococcal protein A (SPA) bacterial rose ring for carcino-embryonic antigen (CEA) by radioimmunoassay, and the relationship between T lymphocyte. CEA and Syndrome of TCM was explored. The results were as follows:the values of OKT3, OKT4, OKT4/OKT8 were lower in the lung carcinoma than that in healthy subjects (P < 0.05-0.01), but OKT8 was higher (P < 0.05); The values of T lymphocyte lowered or increased in the order of Yin Deficiency with internal Heat, Qi Stagnation with blood stasis, Phlegm-Dampness in Lung, Qi-Yin Deficiency, but that of CEA was the highest in Qi-stagnation with blood stasis. There was a significant difference between all Syndrome-types of TCM and the healthy subjects (P < 0.01). Therefore, it is suggested that the values of peripheral T lymphocytes and CEA with the lung carcinoma were regarded as good referential parameters in reflection the condition of Deficiency in Vitality and Excess in Superficiality, which offered the objective evidence for the TCM treatment.
采用直接金黄色葡萄球菌A蛋白（SPA）花环法检测56例肺癌患者外周血T淋巴细胞，用放射免疫法检测癌胚抗原（CEA），探讨T淋巴细胞、CEA与中医证型的关系。结果如下：肺癌患者OKT3、OKT4、OKT4/OKT8值低于健康人（P＜0.05～0.01），而OKT8值高于健康人（P＜0.05）；T淋巴细胞值按阴虚内热、气滞血瘀、痰湿阻肺、气阴两虚顺序降低或升高，而CEA值以气滞血瘀型最高。各中医证型与健康人比较差异有显著性（P＜0.01）。提示肺癌外周血T淋巴细胞及CEA值可作为反映虚实状态的良好参考指标，为中医治疗提供客观依据。
