Adelman J P
Vollum Institute, Oregon Health Sciences University, Portland, USA.
Curr Opin Neurobiol. 1995 Jun;5(3):286-95. doi: 10.1016/0959-4388(95)80040-9.
Voltage-gated ion channels are composed of pore-forming subunits, as well as auxiliary subunits that modify the functions of these channels. In addition, the channels interact with other modulatory proteins in a more transient manner, although with significant effects on channel activity. Even though many second-messenger systems influence the voltage-gated ion channels, only in a few cases has clear evidence for direct protein-protein interactions been demonstrated. Recent biochemical and genetic studies have helped to elucidate the scope of the interactions between these ion channels and various modulatory proteins by determining the structures and functions of nonpore-forming subunits.
电压门控离子通道由形成孔道的亚基以及修饰这些通道功能的辅助亚基组成。此外，这些通道以更短暂的方式与其他调节蛋白相互作用，尽管对通道活性有显著影响。尽管许多第二信使系统会影响电压门控离子通道，但只有在少数情况下才证明有直接蛋白质 - 蛋白质相互作用的明确证据。最近的生化和遗传学研究通过确定非孔道形成亚基的结构和功能，有助于阐明这些离子通道与各种调节蛋白之间相互作用的范围。
