谷氨酸受体辅助亚基的定义标准。
Defined criteria for auxiliary subunits of glutamate receptors.
机构信息
Program in Cellular Neuroscience, Neurodegeneration and Repair, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA.
出版信息
J Physiol. 2012 Jan 1;590(1):21-31. doi: 10.1113/jphysiol.2011.213868. Epub 2011 Sep 26.
Abstract
Pore-forming subunits of ion channels show channel activity in heterologous cells. However, recombinant and native channels often differ in their channel properties. These discrepancies are resolved by the identification of channel auxiliary subunits. In this review article, an auxiliary subunit of ligand-gated ion channels is defined using four criteria: (1) as a Non-pore-forming subunit, (2) direct and stable interaction with a pore-forming subunit, (3) modulation of channel properties and/or trafficking in heterologous cells, (4) necessity in vivo. We focus particularly on three classes of ionotropic glutamate receptors and their transmembrane interactors. Precise identification of auxiliary subunits and reconstruction of native glutamate receptors will open new directions to understanding the brain and its functions.
摘要
离子通道的孔形成亚基在异源细胞中显示通道活性。然而，重组和天然通道在其通道特性上常常存在差异。这些差异通过鉴定通道辅助亚基得到解决。在这篇综述文章中，使用四个标准定义配体门控离子通道的辅助亚基：(1) 作为非孔形成亚基，(2) 与孔形成亚基直接且稳定的相互作用，(3) 在异源细胞中调节通道特性和/或运输，(4) 在体内的必要性。我们特别关注三类离子型谷氨酸受体及其跨膜相互作用物。辅助亚基的精确鉴定和天然谷氨酸受体的重建将为理解大脑及其功能开辟新的方向。
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Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1. kainate 受体在大脑中的不同功能是由辅助亚基 Neto1 决定的。
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Synaptic targeting and functional modulation of GluK1 kainate receptors by the auxiliary neuropilin and tolloid-like (NETO) proteins.神经钙黏蛋白和 tolloid 样（NETO）蛋白对 GluK1 型 kainate 受体的突触靶向作用和功能调节。
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