Trimmer J S
Department of Biochemistry and Cell Biology, State University of New York, Stony Brook 11794-5215, USA.
Curr Opin Neurobiol. 1998 Jun;8(3):370-4. doi: 10.1016/s0959-4388(98)80063-9.
Neuronal and cardiac voltage-gated ion channels contain auxiliary subunits that can profoundly affect the gating of the pore-forming and voltage-sensing alpha subunits. Recent studies on the structurally similar cytoplasmic beta subunits of Ca2+ and K+ channels reveal that these subunits can also exert profound effects on the expression of the integral membrane protein channel components. The mechanisms by which these effects occur are now being elucidated through a combined approach that employs biophysical, pharmacological, cell biological and biochemical techniques.
神经元和心脏电压门控离子通道包含辅助亚基，这些亚基可深刻影响形成孔道和感受电压的α亚基的门控。最近对结构相似的Ca2+和K+通道胞质β亚基的研究表明，这些亚基也可对整合膜蛋白通道成分的表达产生深远影响。现在正通过综合运用生物物理、药理学、细胞生物学和生物化学技术的方法来阐明这些效应产生的机制。
